<i>Carica papaya’s </i>Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet

Etaga Noel Babayana; Selakong Nzekuie Quelie; Etoundi Omgba Cunegonde Blanche; Mekoulou Ndongo Jerson; Bika Lélé Claude Élisé; Aicha De Nkainsa; Ngaha Marie Ide; Bilog Nadine Carole; Bogning Zangueu Calvin; Mbock Armel Junior; Endougou Effa Anne Marie; Dongmo Alain Bernard; Bongue Bienvenu; Mandengue Samuel Honoré; Ayina Ayina Clarisse Noel

doi:doi:10.11648/j.ijnfs.20211005.13

Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet

Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, Aicha De Nkainsa, Ngaha Marie Ide, Bilog Nadine Carole, Bogning Zangueu Calvin, Mbock Armel Junior, Endougou Effa Anne Marie, Dongmo Alain Bernard, Bongue Bienvenu, Mandengue Samuel Honoré, Ayina Ayina Clarisse Noel

Published in International Journal of Nutrition and Food Sciences (Volume 10, Issue 5)

Received: 11 August 2021 Accepted: 2 September 2021 Published: 12 October 2021

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Abstract

In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.

Published in	International Journal of Nutrition and Food Sciences (Volume 10, Issue 5)
DOI	10.11648/j.ijnfs.20211005.13
Page(s)	108-116
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pawpaw (Carica papaya), Oxidised Palm Oil, Sucrose, Obesity, Insulin Resistance

References

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Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, et al. (2021). Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. International Journal of Nutrition and Food Sciences, 10(5), 108-116. https://doi.org/10.11648/j.ijnfs.20211005.13

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ACS Style

Etaga Noel Babayana; Selakong Nzekuie Quelie; Etoundi Omgba Cunegonde Blanche; Mekoulou Ndongo Jerson; Bika Lélé Claude Élisé, et al. Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. Int. J. Nutr. Food Sci. 2021, 10(5), 108-116. doi: 10.11648/j.ijnfs.20211005.13

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AMA Style

Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, et al. Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. Int J Nutr Food Sci. 2021;10(5):108-116. doi: 10.11648/j.ijnfs.20211005.13

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@article{10.11648/j.ijnfs.20211005.13,
  author = {Etaga Noel Babayana and Selakong Nzekuie Quelie and Etoundi Omgba Cunegonde Blanche and Mekoulou Ndongo Jerson and Bika Lélé Claude Élisé and Aicha De Nkainsa and Ngaha Marie Ide and Bilog Nadine Carole and Bogning Zangueu Calvin and Mbock Armel Junior and Endougou Effa Anne Marie and Dongmo Alain Bernard and Bongue Bienvenu and Mandengue Samuel Honoré and Ayina Ayina Clarisse Noel},
  title = {Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {10},
  number = {5},
  pages = {108-116},
  doi = {10.11648/j.ijnfs.20211005.13},
  url = {https://doi.org/10.11648/j.ijnfs.20211005.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20211005.13},
  abstract = {In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.},
 year = {2021}
}

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TY  - JOUR
T1  - Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet
AU  - Etaga Noel Babayana
AU  - Selakong Nzekuie Quelie
AU  - Etoundi Omgba Cunegonde Blanche
AU  - Mekoulou Ndongo Jerson
AU  - Bika Lélé Claude Élisé
AU  - Aicha De Nkainsa
AU  - Ngaha Marie Ide
AU  - Bilog Nadine Carole
AU  - Bogning Zangueu Calvin
AU  - Mbock Armel Junior
AU  - Endougou Effa Anne Marie
AU  - Dongmo Alain Bernard
AU  - Bongue Bienvenu
AU  - Mandengue Samuel Honoré
AU  - Ayina Ayina Clarisse Noel
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ijnfs.20211005.13
DO  - 10.11648/j.ijnfs.20211005.13
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 108
EP  - 116
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20211005.13
AB  - In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.
VL  - 10
IS  - 5
ER  -

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Author Information

Etaga Noel Babayana

Department of Animal and Biology, University of Douala, Douala, Cameroun
Selakong Nzekuie Quelie

Department of Animal and Biology, University of Douala, Douala, Cameroun
Etoundi Omgba Cunegonde Blanche

Department of Biochemistry, University of Douala, Douala, Cameroun
Mekoulou Ndongo Jerson

Department of Animal and Biology, University of Douala, Douala, Cameroun
Bika Lélé Claude Élisé
Aicha De Nkainsa

Department of Animal and Biology, University of Douala, Douala, Cameroun
Ngaha Marie Ide

Department of Animal and Biology, University of Douala, Douala, Cameroun
Bilog Nadine Carole

Department of Animal and Biology, University of Douala, Douala, Cameroun
Bogning Zangueu Calvin

Department of Animal and Biology, University of Douala, Douala, Cameroun
Mbock Armel Junior

Department of Animal and Biology, University of Douala, Douala, Cameroun
Endougou Effa Anne Marie

Department of Animal and Biology, University of Douala, Douala, Cameroun
Dongmo Alain Bernard

Department of Animal and Biology, University of Douala, Douala, Cameroun
Bongue Bienvenu

Laboratoire SAINBIOSE INSERM U1059, Université Jean Monnet, Saint Etienne, France
Mandengue Samuel Honoré

Department of Animal and Biology, University of Douala, Douala, Cameroun
Ayina Ayina Clarisse Noel

Department of Animal and Biology, University of Douala, Douala, Cameroun

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Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, et al. (2021). Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. International Journal of Nutrition and Food Sciences, 10(5), 108-116. https://doi.org/10.11648/j.ijnfs.20211005.13

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ACS Style

Etaga Noel Babayana; Selakong Nzekuie Quelie; Etoundi Omgba Cunegonde Blanche; Mekoulou Ndongo Jerson; Bika Lélé Claude Élisé, et al. Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. Int. J. Nutr. Food Sci. 2021, 10(5), 108-116. doi: 10.11648/j.ijnfs.20211005.13

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AMA Style

Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, et al. Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. Int J Nutr Food Sci. 2021;10(5):108-116. doi: 10.11648/j.ijnfs.20211005.13

Copy | Download

@article{10.11648/j.ijnfs.20211005.13,
  author = {Etaga Noel Babayana and Selakong Nzekuie Quelie and Etoundi Omgba Cunegonde Blanche and Mekoulou Ndongo Jerson and Bika Lélé Claude Élisé and Aicha De Nkainsa and Ngaha Marie Ide and Bilog Nadine Carole and Bogning Zangueu Calvin and Mbock Armel Junior and Endougou Effa Anne Marie and Dongmo Alain Bernard and Bongue Bienvenu and Mandengue Samuel Honoré and Ayina Ayina Clarisse Noel},
  title = {Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {10},
  number = {5},
  pages = {108-116},
  doi = {10.11648/j.ijnfs.20211005.13},
  url = {https://doi.org/10.11648/j.ijnfs.20211005.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20211005.13},
  abstract = {In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.},
 year = {2021}
}

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TY  - JOUR
T1  - Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet
AU  - Etaga Noel Babayana
AU  - Selakong Nzekuie Quelie
AU  - Etoundi Omgba Cunegonde Blanche
AU  - Mekoulou Ndongo Jerson
AU  - Bika Lélé Claude Élisé
AU  - Aicha De Nkainsa
AU  - Ngaha Marie Ide
AU  - Bilog Nadine Carole
AU  - Bogning Zangueu Calvin
AU  - Mbock Armel Junior
AU  - Endougou Effa Anne Marie
AU  - Dongmo Alain Bernard
AU  - Bongue Bienvenu
AU  - Mandengue Samuel Honoré
AU  - Ayina Ayina Clarisse Noel
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ijnfs.20211005.13
DO  - 10.11648/j.ijnfs.20211005.13
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 108
EP  - 116
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20211005.13
AB  - In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.
VL  - 10
IS  - 5
ER  -

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